Prognostic significance of the TEL-AML1 fusion gene in pediatric acute lymphoblastic leukemia in Turkey

ÖZBEK, UĞUR; Sirma, S; Agaoglu, L; Yuksel, L; Anak, S; Yildiz, I; Devecioglu, O; Timur, C; Meral, A; Gedikoglu, G

doi:10.1097/00043426-200303000-00005

Prognostic significance of the TEL-AML1 fusion gene in pediatric acute lymphoblastic leukemia in Turkey

ÖZBEK U., Sirma S., Agaoglu L., Yuksel L., Anak S., Yildiz I., ...Daha Fazla

JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY, cilt.25, sa.3, ss.204-208, 2003 (SCI-Expanded, Scopus)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 25 Sayı: 3
Basım Tarihi: 2003
Doi Numarası: 10.1097/00043426-200303000-00005
Dergi Adı: JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.204-208
Anahtar Kelimeler: acute lymphoblastic leukemia, pediatric leukemia, TEL-AML1, TEL/AML1 FUSION, CRYPTIC T(12-21), CHILDHOOD, CHILDREN, TRANSCRIPT, FREQUENCY, SUBGROUP, RELAPSE
Acıbadem Mehmet Ali Aydınlar Üniversitesi Adresli: Hayır

Özet

Purpose: The t(12;21) translocation is the most common reciprocal chromosomal rearrangement in pediatric acute lymphoblastic leukemia (ALL). This translocation fuses two genes, TEL and AML1, and results in the production of the TEL-AML1 fusion protein. The authors investigated the incidence and prognostic significance of the TEL-AML1 fusion gene in patients with ALL in Turkey.