Prognostic significance of the TEL-AML1 fusion gene in pediatric acute lymphoblastic leukemia in Turkey


ÖZBEK U., Sirma S., Agaoglu L., Yuksel L., Anak S., Yildiz I., ...Daha Fazla

JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY, cilt.25, sa.3, ss.204-208, 2003 (SCI-Expanded) identifier identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 25 Sayı: 3
  • Basım Tarihi: 2003
  • Doi Numarası: 10.1097/00043426-200303000-00005
  • Dergi Adı: JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.204-208
  • Anahtar Kelimeler: acute lymphoblastic leukemia, pediatric leukemia, TEL-AML1, TEL/AML1 FUSION, CRYPTIC T(12-21), CHILDHOOD, CHILDREN, TRANSCRIPT, FREQUENCY, SUBGROUP, RELAPSE
  • Acıbadem Mehmet Ali Aydınlar Üniversitesi Adresli: Hayır

Özet

Purpose: The t(12;21) translocation is the most common reciprocal chromosomal rearrangement in pediatric acute lymphoblastic leukemia (ALL). This translocation fuses two genes, TEL and AML1, and results in the production of the TEL-AML1 fusion protein. The authors investigated the incidence and prognostic significance of the TEL-AML1 fusion gene in patients with ALL in Turkey.