Prognostic significance of the TEL-AML1 fusion gene in pediatric acute lymphoblastic leukemia in Turkey

ÖZBEK U., Sirma S., Agaoglu L., Yuksel L., Anak S., Yildiz I., ...More

JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY, vol.25, no.3, pp.204-208, 2003 (SCI-Expanded, Scopus) identifier identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 25 Issue: 3
  • Publication Date: 2003
  • Doi Number: 10.1097/00043426-200303000-00005
  • Journal Name: JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.204-208
  • Keywords: acute lymphoblastic leukemia, pediatric leukemia, TEL-AML1, TEL/AML1 FUSION, CRYPTIC T(12-21), CHILDHOOD, CHILDREN, TRANSCRIPT, FREQUENCY, SUBGROUP, RELAPSE
  • Acibadem Mehmet Ali Aydinlar University Affiliated: No

Abstract

Purpose: The t(12;21) translocation is the most common reciprocal chromosomal rearrangement in pediatric acute lymphoblastic leukemia (ALL). This translocation fuses two genes, TEL and AML1, and results in the production of the TEL-AML1 fusion protein. The authors investigated the incidence and prognostic significance of the TEL-AML1 fusion gene in patients with ALL in Turkey.