Evaluation of the genes for the adrenergic receptors alpha 2A and alpha 1C and Gilles de la Tourette syndrome

Xu C., Ozbay F., Wigg K., Shulman R., Tahir E., Yazgan Y., ...More

AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS, vol.119B, no.1, pp.54-59, 2003 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 119B Issue: 1
  • Publication Date: 2003
  • Doi Number: 10.1002/ajmg.b.20001
  • Journal Name: AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.54-59
  • Keywords: Gilles de la Tourette syndrome, genetics, adrenergic receptor alpha 1C (alpha la), adrenergic receptor alpha 2A, linkage, DEFICIT HYPERACTIVITY DISORDER, ATTENTION, LINKAGE, POLYMORPHISM, RELIABILITY, SEGREGATION, INTERVIEW, GENOME, REGION, FAMILY
  • Acibadem Mehmet Ali Aydinlar University Affiliated: Yes

Abstract

Gilles de la Tourette Syndrome (GTS) has long been known to be familial, and evidence from twin studies indicates that it has a substantial genetic component. Our genome scan of sibling pair families with GTS found evidence suggestive of linkage to several chromosomal locations. On the basis of these findings, we have begun to study additional markers in these regions, with some of the markers located in candidate genes. Two candidate genes stand out in these regions: the adrenergic receptor alpha1C(1A) (ADRA1C) located on chromosome 8p and the adrenergic receptor alpha2A (ADRA2A) located on chromosome 10q. The adrenergic system has been suggested to play a role in GTS based on the reduction of symptoms with the adrenergic receptor agonists, clonidine and guanfacine. We examined the inheritance of polymorphisms in the ADRA2A and ADRA1C genes in 113 nuclear families identified through a GTS proband. We found no significant evidence for linkage using the transmission disequilibrium test for these two genes. Based on our families, we conclude that these genes are not major genetic factors contributing to the susceptibility to GTS. (C) 2003 Wiley-Liss, Inc.