Methylsulfonyl Zn phthalocyanine: A polyvalent and powerful hydrophobic photosensitizer with a wide spectrum of photodynamic applications

Isci U., Beyreis M., Tortik N., Topal S. Z., Glueck M., Ahsen V., ...More

PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY, vol.13, pp.40-47, 2016 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 13
  • Publication Date: 2016
  • Doi Number: 10.1016/j.pdpdt.2015.10.010
  • Journal Name: PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.40-47
  • Keywords: Photodynamic therapy, Photodynamic inactivation, Phthalocyanine, Singlet oxygen generation, In vitro, INACTIVATION, THERAPY, FORMULATIONS, CANCER
  • Acibadem Mehmet Ali Aydinlar University Affiliated: Yes

Abstract

Background: The biomedical photodynamic principle is based on the light-induced and photosensitizer-mediated killing of unwanted or harmful cells by overproduction of reactive oxygen species. Motivated by the success of photodynamic therapy (PDT) against several types of tumors, further applications of this approach are constantly identified which require the design and synthesis of novel photosensitizers with specifically tailored properties for a particular clinical application.