Akademik Veri Yönetim Sistemi
JOURNAL OF CARDIOTHORACIC AND VASCULAR ANESTHESIA, cilt.17, sa.6, ss.721-724, 2003 (SCI-Expanded)
Objective: To investigate the dose-related effects of theophylline in prevention of ischemia-reperfusion injury of the lung. Design: Experimental study. Settings: University hospital. Participants: Thirty Wistar rats. Interventions: In experimental group 1 (G-I) In = 5) 20 mg/L, in G-II (n = 5) 100 mg/L, in G-III (n = 5) 400 mg/L, and in G-IV (n = 5) 1000 mg/L of theophylline was added to modified Euro-Collins solution and perfused the lungs. Lungs were extracted without an ischemic period in control group 1 (C-I) and perfused with modified Euro-Collins solution in control group 2 (C-II). Lungs were kept in a hypothermic state for 6 hours and then ventilated for 30 minutes with 100% O-2. Measurements and Main Results: Tissue levels of then congugate (DC) and malonylaldehyde (MDA) were measured. Comparison of 6 groups revealed statistically significant differences for DC and MDA (p < 0.0001 for both comparisons). Both DC and MDA levels of C-II were found to be higher than G-III and G-IV (p = 0.008). DC and MDA levels of G-III and G-IV were significantly lower than G-I and G-II (p 0.008 for all comparisons). Conclusion: The results of this study showed that 400 mg/L and 1000 mg/L of theophylline added to the modified Euro-Collins solution decreased the intermediate products of lipid peroxidation. Theophylline merits further investigation in ischemia-reperfusion studies as a potentially beneficial agent. (C) 2003 Elsevier Inc. All rights reserved.