Effects of valproate, phenytoin, and MK-801 in a novel model of epileptogenesis

Applegate C., Samoriski G., Ozduman K.

EPILEPSIA, vol.38, no.6, pp.631-636, 1997 (Peer-Reviewed Journal) identifier identifier identifier

  • Publication Type: Article / Editorial Material
  • Volume: 38 Issue: 6
  • Publication Date: 1997
  • Doi Number: 10.1111/j.1528-1157.1997.tb01231.x
  • Journal Name: EPILEPSIA
  • Journal Indexes: Science Citation Index Expanded
  • Page Numbers: pp.631-636
  • Keywords: flurothyl, generalized seizures, seizure propagation, seizure threshold, epileptogenesis, C57BL/6J mice, KINDLING MODEL, SEIZURES, RATS, ELECTROSHOCK, EPILEPSY, LESION


Purpose: We have developed and characterized a novel model of epileptogenesis based on the convulsive actions of flurothyl in mice. The hallmark feature of this model is a reliable change in the type of seizure expressed in response to flurothyl from generalized clonic to generalized tonic seizures. The purpose of our study was to evaluate the effects of chronic administration of valproate (VPA), phenytoin (PHT), and MK-801 on the change in seizure phenotype observed in our model system.