Effects of valproate, phenytoin, and MK-801 in a novel model of epileptogenesis

Applegate C., Samoriski G., Ozduman K.

EPILEPSIA, cilt.38, sa.6, ss.631-636, 1997 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Editöre Mektup
  • Cilt numarası: 38 Sayı: 6
  • Basım Tarihi: 1997
  • Doi Numarası: 10.1111/j.1528-1157.1997.tb01231.x
  • Dergi Adı: EPILEPSIA
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.631-636
  • Anahtar Kelimeler: flurothyl, generalized seizures, seizure propagation, seizure threshold, epileptogenesis, C57BL/6J mice, KINDLING MODEL, SEIZURES, RATS, ELECTROSHOCK, EPILEPSY, LESION
  • Acıbadem Mehmet Ali Aydınlar Üniversitesi Adresli: Hayır

Özet

Purpose: We have developed and characterized a novel model of epileptogenesis based on the convulsive actions of flurothyl in mice. The hallmark feature of this model is a reliable change in the type of seizure expressed in response to flurothyl from generalized clonic to generalized tonic seizures. The purpose of our study was to evaluate the effects of chronic administration of valproate (VPA), phenytoin (PHT), and MK-801 on the change in seizure phenotype observed in our model system.