Effects of valproate, phenytoin, and MK-801 in a novel model of epileptogenesis

Applegate C., Samoriski G., Ozduman K.

EPILEPSIA, vol.38, no.6, pp.631-636, 1997 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Editorial Material
  • Volume: 38 Issue: 6
  • Publication Date: 1997
  • Doi Number: 10.1111/j.1528-1157.1997.tb01231.x
  • Title of Journal : EPILEPSIA
  • Page Numbers: pp.631-636


Purpose: We have developed and characterized a novel model of epileptogenesis based on the convulsive actions of flurothyl in mice. The hallmark feature of this model is a reliable change in the type of seizure expressed in response to flurothyl from generalized clonic to generalized tonic seizures. The purpose of our study was to evaluate the effects of chronic administration of valproate (VPA), phenytoin (PHT), and MK-801 on the change in seizure phenotype observed in our model system.