Effects of peroxisome proliferator activated receptor gamma (PPAR gamma) agonist on fasting model applied neuron cultures

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Pinarbasi A., Pak M., Kolay M., ÖZ ARSLAN D., Aksungar F.

TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI, vol.47, no.1, pp.41-48, 2022 (SCI-Expanded) identifier

  • Publication Type: Article / Article
  • Volume: 47 Issue: 1
  • Publication Date: 2022
  • Doi Number: 10.1515/tjb-2021-0104
  • Journal Name: TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, EMBASE, Food Science & Technology Abstracts, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.41-48
  • Keywords: fasting, ketone bodies, neuron cultures, pioglitazone, PPAR gamma, MITOCHONDRIAL-FUNCTION, COMPLEX I, MACROPHAGES, EXPRESSION, BODIES, TARGET
  • Acibadem Mehmet Ali Aydinlar University Affiliated: Yes

Abstract

Objectives: Peroxisome proliferator activated receptor gamma (PPAR gamma) agonists used for the treatment of Diabetes Mellitus (DM), has important roles on the regulation of metabolism including ketogenesis in fasting and low glucose states. Recently PPAR gamma was proven to have antioxidant and anti-inflammatory effects on neuronal cells.