CD27 expression on lymphocyte and sCD27 levels in children with asthma

Bozdogan G. , Dogu F., Guloglu D., Yuksek M., Aytekin C., Ikinciogullari A.

ALLERGOLOGIA ET IMMUNOPATHOLOGIA, cilt.38, sa.6, ss.327-332, 2010 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 38 Konu: 6
  • Basım Tarihi: 2010
  • Doi Numarası: 10.1016/j.aller.2010.02.008
  • Sayfa Sayıları: ss.327-332


Background: CD27, a lymphocyte specific member of the Tumour Necrosis Factor-Receptor (TNF-R) family is expressed on the majority of peripheral blood T cells. Activation of T cells via TCR/CD3 induces high CD27 surface expression and release of a soluble form (sCD27) of the molecule. sCD27 level increases in patients suffering from a variety of chronic inflammatory diseases. In the present study we aimed to measure both the serum sCD27 levels and CD27 expression on T cells in asthmatic patients, to evaluate the state of this molecule in allergic inflammation.