CD27 expression on lymphocyte and sCD27 levels in children with asthma


Bozdogan G. , Dogu F., Guloglu D., Yuksek M., Aytekin C., Ikinciogullari A.

ALLERGOLOGIA ET IMMUNOPATHOLOGIA, vol.38, no.6, pp.327-332, 2010 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 38 Issue: 6
  • Publication Date: 2010
  • Doi Number: 10.1016/j.aller.2010.02.008
  • Title of Journal : ALLERGOLOGIA ET IMMUNOPATHOLOGIA
  • Page Numbers: pp.327-332

Abstract

Background: CD27, a lymphocyte specific member of the Tumour Necrosis Factor-Receptor (TNF-R) family is expressed on the majority of peripheral blood T cells. Activation of T cells via TCR/CD3 induces high CD27 surface expression and release of a soluble form (sCD27) of the molecule. sCD27 level increases in patients suffering from a variety of chronic inflammatory diseases. In the present study we aimed to measure both the serum sCD27 levels and CD27 expression on T cells in asthmatic patients, to evaluate the state of this molecule in allergic inflammation.