Extramedullary relapse in the pleura in acute promyelocytic leukemia

Disel U., Yavuz S., Paydas S., Sahin B., Zeren H.

LEUKEMIA & LYMPHOMA, vol.44, no.1, pp.189-191, 2003 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 44 Issue: 1
  • Publication Date: 2003
  • Doi Number: 10.1080/1042819031000057270
  • Title of Journal : LEUKEMIA & LYMPHOMA
  • Page Numbers: pp.189-191
  • Keywords: extramedullary relapse, pleural tumor, acute promyelocytic leukemia, ATRA, TRANS-RETINOIC ACID, INVOLVEMENT


Acute promyelocytic leukemia (APL) is a distinct subtype of acute myeloblastic leukemia with specific clinical, morphologic and genetic features and a good response to all trans retinoic acid ( ATRA). However, extramedullary (EM) relapse is an interesting feature of these cases, especially those treated with ATRA. Recently, we have encountered an EM relapse in the pleura in a case with APL receiving an ATRA containing regimen. This case is reported and the relevant literature is reviewed.