Neurosurgical follow-up and treatment of a series of 26 WHO grade III meningiomas

GUDUK M., Eksi M. S., BOZKURT B., USSELİ M. İ., ERŞEN DANYELİ A., Pamir M. N.

JOURNAL OF CLINICAL NEUROSCIENCE, cilt.91, ss.219-225, 2021 (SCI-Expanded) identifier identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 91
  • Basım Tarihi: 2021
  • Doi Numarası: 10.1016/j.jocn.2021.06.047
  • Dergi Adı: JOURNAL OF CLINICAL NEUROSCIENCE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, EMBASE, MEDLINE
  • Sayfa Sayıları: ss.219-225
  • Anahtar Kelimeler: Meningiomas, Grade III meningiomas, Anaplastic meningiomas, Rhabdoid meningiomas, Papillary meningiomas, PROGRESSION-FREE SURVIVAL, ANAPLASTIC MENINGIOMAS, ATYPICAL MENINGIOMA, PROGNOSTIC-FACTORS, INTRACRANIAL MENINGIOMAS, CLINICAL-SERIES, RISK-FACTORS, PATIENT AGE, CLASSIFICATION, RECURRENCE
  • Acıbadem Mehmet Ali Aydınlar Üniversitesi Adresli: Evet

Özet

Meningiomas are the most common primary intracranial tumors. They have three pathologic grades. Surgical resection aiming Simpson I resection is the standard treatment for meningiomas. Radiotherapy and Gamma Knife radiosurgery are the main adjuvant and salvage treatments. Chemotherapy has limited use. Grade II, and III meningiomas have a higher recurrence rate, and adjuvant radiotherapy is usually the standard treatment for grade III meningiomas. In this paper, we analyzed our meningioma series of 1401 patients and presented the treatment and follow-up results of 26 grade III meningioma cases. Median follow-up of grade III meningiomas was 40.5 (range, 1-154) months. The mean age of patients was 51.7 +/- 15.7 years; 12 of them were female and 14 were male (female/male ratio = 0.9). The median progression-free survival (PFS) of them was 22 months, and overall survival (OS) was 62 months. Meningiomas with gross total resection (GTR), non-skull base meningiomas, and primary grade III meningiomas had longer PFS, while meningiomas with GTR, non-skull base meningiomas, and primary meningiomas had longer OS with a statistical significance. (c) 2021 Elsevier Ltd. All rights reserved.