A Proteomic Analysis of Mitochondrial Complex III Inhibition in SH-SY5Y Human Neuroblastoma Cell Line

Acioglu C., Tuzuner M. B., Serhatli M., Acilan C., Sahin B., Akgun E., ...More

CURRENT PROTEOMICS, vol.16, pp.136-147, 2019 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 16
  • Publication Date: 2019
  • Doi Number: 10.2174/1570164615666180713110139
  • Journal Name: CURRENT PROTEOMICS
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED)
  • Page Numbers: pp.136-147
  • Acibadem Mehmet Ali Aydinlar University Affiliated: Yes

Abstract

Background and Objective: Antimycin A (AntA) is a potent Electron Transport System (ETS) inhibitor exerting its effect through inhibiting the transfer of the electrons by binding to the quinone reduction site of the cytochrome bcl complex (Complex III), which is known to be impaired in Huntington's Disease (HD). The current studies were undertaken to investigate the effect of complex III inhibition in the SH-SY5Y cell line to delineate the molecular and cellular processes, which may play a role in the pathogenesis of HD.