The impact of neoadjuvant therapy on the histopathological features of pancreatic ductal adenocarcinoma - A systematic review and meta-analysis


Schorn S., Demir I. E. , Reyes C. M. , Saricaoglu C., Samm N., Schirren R., ...More

CANCER TREATMENT REVIEWS, vol.55, pp.96-106, 2017 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Review
  • Volume: 55
  • Publication Date: 2017
  • Doi Number: 10.1016/j.ctrv.2017.03.003
  • Title of Journal : CANCER TREATMENT REVIEWS
  • Page Numbers: pp.96-106

Abstract

Background: Due to increased rates of curative tumor resections exceeding 60% after FOLFIRINOX-treatment, neoadjuvant therapy/NTx is increasingly recognized as an effective therapy option for down staging borderline or locally advanced pancreatic ductal adenocarcinoma/PDAC. Yet, the effects of NTx on the common histopathological features of PDAC have not been systematically analysed. Therefore, the aim of the current study was to assess the impact of NTx on relevant histopathological features of PDAC.