Akademik Veri Yönetim Sistemi
JBJS REVIEWS, sa.8, 2014 (ESCI)
Molecular methods that involve the use of technology such as polymerase chain reaction to amplify existing bacteria can increase the likelihood of identifying the pathogen responsible for periprosthetic joint infection. Synovial biomarkers, such as C-reactiveprotein (CRP), leukocyte esterase, alpha-defensin, human beta-defensin-2 (HBD-2) and HBD-3, and cathelicidin LL-37 are elevated in patients with periprosthetic joint infection and may be valuable markers for diagnosing such an infection with use of point-of-care devices. Serum biomarkers, such as interleukin (IL)-4, IL-6, procalcitonin, and soluble intercellular adhesion molecule-1 (sICAM-1), have been shown to be elevated in patients with periprosthetic joint infection and may provide markers for diagnosing such an infection and for determining the proper time to perform reimplantation.