Late onset polyneuropathy due to organophosphate (DDVP) intoxication

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Sevim S., Aktekin M., Dogu O., Ozturk H., Ertas M.

CANADIAN JOURNAL OF NEUROLOGICAL SCIENCES, vol.30, no.1, pp.75-78, 2003 (Peer-Reviewed Journal) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 30 Issue: 1
  • Publication Date: 2003
  • Doi Number: 10.1017/s0317167100002493
  • Journal Indexes: Science Citation Index Expanded
  • Page Numbers: pp.75-78


Background: Organophosphate intoxication can cause some well-known life threatening acute neurological complications such as seizures, paralysis, neuromuscular and cardiac conduction disorders. Less often, a predominantly motor and delayed axonal neuropathy can occur. This syndrome is due to inhibition of neuropathy target esterase. Case Report: A 30-year-old woman attempted suicide by drinking approximately 1000mg/kg dimethyl-2,2-dichloro vinyl phosphate (DDVP). After a muscarinic and cholinergic syndrome lasting four days, she developed a purely motor distal axonal polyneuropathy on the fifth week after ingestion confirmed by electroneuromyography and sural nerve biopsy. Neurological examination and electroneuromyography revealed a slight recovery at the end of the 21st month. Conclusion: This case of late onset polyneuropathy caused by organophosphate intoxication had unusual features such as intact sensory nerves and worse prognosis when compared to previously reported cases.