Akademik Veri Yönetim Sistemi
Journal of Radiation Research and Applied Sciences, cilt.17, sa.3, ss.1-9, 2024 (SCI-Expanded)
Purpose: In study, it was aimed to evaluate the dose volume histograms (DVH) of extended SSD technique, VMAT
based, and helical tomotherapy plans dosimetrically in a multi-institutional context to achieve higher plan
quality and to harmonize total body irradiation plans.
Methods: Four different clinical centers participated in the study. The CT images of ten patients were used in this
study. During the first phase, ten patients enrolled for TBI were planned by multiple centers according to a
common protocol. During the second phase, all centers shared their plans’ DVHs. Treatment plans were evalu
ated according to the critical organ dose limits. Statistical analysis was performed in the SPSS (version 22.0)
program (p < 0.05).
Results: In study, the results indicated that there was a statistically significant and considerable difference in the
dose coverage of PTV, beam delivery time and MU, lens doses, and kidney doses between the four techniques (p
<0.001). The mean lung doses of the four centers were below 10 Gy. No significant difference in maximum liver
doses between plans was obtained.
Conclusion: In conclusion, although four treatment techniques were suitable for TBI treatment, more homoge
neous dose distribution, and lower critical organ doses were obtained with the tomotherapy technique. However,
treatment time, MU, and dose rate for lung were disadvantages of the tomotherapy technique. When it comes to
deciding on the TBI treatment method, it need to be reviewed some important points. It is needed to sufficient
data on long-term results to be able to standardize TBI techniques between centers