Photoproperties, PVP formulation and F-19 NMR of a Zn phthalocyanine with 24 magnetically pseudo-equivalent fluorine atoms


Kucuk T., Alpugan S., Davarci D., Pehlivan E. G. , Bayir S., Tazebay U. H. , ...More

JOURNAL OF PORPHYRINS AND PHTHALOCYANINES, vol.23, pp.611-618, 2019 (Journal Indexed in SCI) identifier identifier

  • Publication Type: Article / Article
  • Volume: 23
  • Publication Date: 2019
  • Doi Number: 10.1142/s1088424619500512
  • Title of Journal : JOURNAL OF PORPHYRINS AND PHTHALOCYANINES
  • Page Numbers: pp.611-618

Abstract

In an attempt to investigate its potential as a PDT F-19 MRI molecular theranostic, a Zn phthalocyanine with 24 pseudo-equivalent fluorine atoms was designed and prepared. Compared to its H analogues, the fluorinated derivative has a much higher generation of singlet oxygen. F-19 NMR signals in CDCl3 showed that all the fluorine atoms are magnetically pseudo-equivalent with only two close fluorine signals. Formulation in PVP (polyvinylpyrrolidone), a FDA-approved additive, enabled water-solubilization of the phthalocyanines but no satisfying F-19 NMR signal could be obtained, probably due to self-quenching caused by aggregation.