Photoproperties, PVP formulation and F-19 NMR of a Zn phthalocyanine with 24 magnetically pseudo-equivalent fluorine atoms

Kucuk T., Alpugan S., Davarci D., Pehlivan E. G., Bayir S., Tazebay U. H., ...Daha Fazla

JOURNAL OF PORPHYRINS AND PHTHALOCYANINES, cilt.23, ss.611-618, 2019 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 23
  • Basım Tarihi: 2019
  • Doi Numarası: 10.1142/s1088424619500512
  • Dergi Adı: JOURNAL OF PORPHYRINS AND PHTHALOCYANINES
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.611-618
  • Acıbadem Mehmet Ali Aydınlar Üniversitesi Adresli: Hayır

Özet

In an attempt to investigate its potential as a PDT F-19 MRI molecular theranostic, a Zn phthalocyanine with 24 pseudo-equivalent fluorine atoms was designed and prepared. Compared to its H analogues, the fluorinated derivative has a much higher generation of singlet oxygen. F-19 NMR signals in CDCl3 showed that all the fluorine atoms are magnetically pseudo-equivalent with only two close fluorine signals. Formulation in PVP (polyvinylpyrrolidone), a FDA-approved additive, enabled water-solubilization of the phthalocyanines but no satisfying F-19 NMR signal could be obtained, probably due to self-quenching caused by aggregation.