Glutamic Acid Decarboxylase Immunoreactivity in the Mossy Fiber Terminals of the Hippocampus of Genetic Absence Epileptic Rats

ŞİRVANCI S., Canillioglu Y., AKAKIN D., Midillioglu S., Yildiz S. D., Onat F., ...Daha Fazla

TURKISH NEUROSURGERY, cilt.21, sa.4, ss.499-503, 2011 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 21 Sayı: 4
  • Basım Tarihi: 2011
  • Doi Numarası: 10.5137/1019-5149.jtn.4353-11.1
  • Dergi Adı: TURKISH NEUROSURGERY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.499-503
  • Anahtar Kelimeler: Genetic absence epilepsy rats from Strasbourg, Glutamic acid decarboxylase, Hippocampus, Immunocytochemistry, Mossy terminal, DENTATE GRANULE CELLS, ACTIVITY-DEPENDENT EXPRESSION, LIMBIC SEIZURES, GABA, ADULT, GYRUS, GAERS, COEXISTENCE, INDUCTION, SYNAPSES
  • Acıbadem Mehmet Ali Aydınlar Üniversitesi Adresli: Hayır

Özet

AIM: Genetic absence epilepsy rats from Strasbourg (GAERS) provide a model of absence epilepsy. Although excessive GABA mediation within the thalamo-cortico-thalamic circuit has been shown to play a role in absence epilepsy, neuronal networks of hippocampus have recently received attention. Glutamic acid decarboxylase (GAD) was previously shown to be increased after convulsive seizures in the mossy fiber terminals (MFTs) of hippocampus. The aim of the present study was to investigate whether the change in the level of this enzyme in convulsive seizures is also observed in rats having genetic absence epilepsy.