Glutamic Acid Decarboxylase Immunoreactivity in the Mossy Fiber Terminals of the Hippocampus of Genetic Absence Epileptic Rats


ŞİRVANCI S., Canillioglu Y., AKAKIN D., Midillioglu S., Yildiz S. D. , Onat F. , ...More

TURKISH NEUROSURGERY, vol.21, no.4, pp.499-503, 2011 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 21 Issue: 4
  • Publication Date: 2011
  • Doi Number: 10.5137/1019-5149.jtn.4353-11.1
  • Title of Journal : TURKISH NEUROSURGERY
  • Page Numbers: pp.499-503
  • Keywords: Genetic absence epilepsy rats from Strasbourg, Glutamic acid decarboxylase, Hippocampus, Immunocytochemistry, Mossy terminal, DENTATE GRANULE CELLS, ACTIVITY-DEPENDENT EXPRESSION, LIMBIC SEIZURES, GABA, ADULT, GYRUS, GAERS, COEXISTENCE, INDUCTION, SYNAPSES

Abstract

AIM: Genetic absence epilepsy rats from Strasbourg (GAERS) provide a model of absence epilepsy. Although excessive GABA mediation within the thalamo-cortico-thalamic circuit has been shown to play a role in absence epilepsy, neuronal networks of hippocampus have recently received attention. Glutamic acid decarboxylase (GAD) was previously shown to be increased after convulsive seizures in the mossy fiber terminals (MFTs) of hippocampus. The aim of the present study was to investigate whether the change in the level of this enzyme in convulsive seizures is also observed in rats having genetic absence epilepsy.