Secondary metabolites from Scutellaria albida L. ssp. velenovskyi (Rech. f.) Greuter & Burdet

Matsa M., Bardakci H., Gousiadou C., Kirmizibekmez H., Skaltsa H.

BIOCHEMICAL SYSTEMATICS AND ECOLOGY, vol.83, pp.71-76, 2019 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 83
  • Publication Date: 2019
  • Doi Number: 10.1016/j.bse.2019.01.006
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.71-76
  • Keywords: Scutellaria albida L. ssp. velenovskyi, S. albida group, Iridoid glycosides, Flavonoids, Phenylethanoid glycosides, Acetogenic glycoside, PHENOLIC-COMPOUNDS, AERIAL PARTS, GLYCOSIDES, IRIDOIDS, CONSTITUENTS, ROOTS
  • Acibadem Mehmet Ali Aydinlar University Affiliated: Yes


Fourteen compounds (Fig.1) were isolated from the aerial parts of Scutellaria albida L. ssp. velenovskyi (Rech. f.) Greuter & Burdet, including four iridoids (1-4) catalpol, macfadienoside, mussaenosidic acid, albidoside; four flavonoids (5-8) hispidulin 7-O-beta-D-glucuronide, scutellarin, xanthomicrol, eriodictyol; four phenylethanoid glycosides (9-12) verbascoside, leucosceptoside A, martynoside, 2-(3-hydroxy-4-methoxy-phenyl)-ethyl-1-O-beta-D-glucopyranoside; the sugar ester 6'-beta-D-glucopyranosyl-E-p-coumarate (13), as well as the acetogenic glucoside (Z)-3-hexenyl-1-O-beta-D-glucopyranosyl-(1 -> 2)-beta-D-glucopyranoside (14). The structures of the isolates were established by means of NMR and HRMS spectral analyses. This is the first phytochemical study on S. velenovskyi and the first report of an acetogenic glycoside in the genus Scutellaria L. A chemical review on the isolated secondary metabolites in this study has been carried out. The chemotaxonomic value of the isolates is also discussed. Based on the literature data, the analysis revealed that the chemical profile of S. velenovskyi is close to that of the taxa belonging to the S. albida group.