Active Subnetwork GA: A Two Stage Genetic Algorithm Approach to Active Subnetwork Search

Ozisik O., Bakir-Gungor B., DİRİ B., SEZERMAN O. U.

CURRENT BIOINFORMATICS, cilt.12, sa.4, ss.320-328, 2017 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 12 Sayı: 4
  • Basım Tarihi: 2017
  • Doi Numarası: 10.2174/1574893611666160527100444
  • Dergi Adı: CURRENT BIOINFORMATICS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.320-328
  • Anahtar Kelimeler: Active subnetwork search, disease associated module, dysfunctional pathway, genetic algorithm, GWAS, rheumatoid arthritis, IDENTIFYING FUNCTIONAL MODULES, RHEUMATOID-ARTHRITIS, GROWTH-FACTOR, EXPRESSION, NETWORK, INFLAMMATION, IDENTIFICATION, CANCER, RECEPTORS, PATHWAYS
  • Acıbadem Mehmet Ali Aydınlar Üniversitesi Adresli: Hayır

Özet

Background: A group of interconnected genes in a protein-protein interaction network that contains most of the disease associated genes is called an active subnetwork. Active subnetwork search is an NP-hard problem. In the last decade, simulated annealing, greedy search, color coding, genetic algorithm, and mathematical programming based methods are proposed for this problem.