Fractalkine/CX3CR1: why a single chemokine-receptor duo bears a major and unique therapeutic potential


D'Haese J. G. , Demir I. E. , Friess H., Ceyhan G.

EXPERT OPINION ON THERAPEUTIC TARGETS, vol.14, no.2, pp.207-219, 2010 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Review
  • Volume: 14 Issue: 2
  • Publication Date: 2010
  • Doi Number: 10.1517/14728220903540265
  • Title of Journal : EXPERT OPINION ON THERAPEUTIC TARGETS
  • Page Numbers: pp.207-219

Abstract

Importance of the field. Fractalkine, also known as CX3CL1, is the unique member of the fourth class of chemokines and mediates both chemotaxis and adhesion of inflammatory cells via its highly selective receptor CX3CR1. Fractalkine mediates inflammatory responses and pain sensation and is involved in the pathogenesis and progression of numerous inflammatory disorders and malignancies.