Fractalkine/CX3CR1: why a single chemokine-receptor duo bears a major and unique therapeutic potential


D'Haese J. G. , Demir I. E. , Friess H., Ceyhan G.

EXPERT OPINION ON THERAPEUTIC TARGETS, cilt.14, ss.207-219, 2010 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 14 Konu: 2
  • Basım Tarihi: 2010
  • Doi Numarası: 10.1517/14728220903540265
  • Dergi Adı: EXPERT OPINION ON THERAPEUTIC TARGETS
  • Sayfa Sayıları: ss.207-219

Özet

Importance of the field. Fractalkine, also known as CX3CL1, is the unique member of the fourth class of chemokines and mediates both chemotaxis and adhesion of inflammatory cells via its highly selective receptor CX3CR1. Fractalkine mediates inflammatory responses and pain sensation and is involved in the pathogenesis and progression of numerous inflammatory disorders and malignancies.