Which is more effective in the prevention of renal ischemia-reperfusion-induced oxidative injury in the early period in mice: interleukin (IL)-10 or anti-IL-12?


Koken T., Serteser M. , Kahraman A., Akbulut G., Dilek O.

CLINICAL BIOCHEMISTRY, cilt.37, ss.50-55, 2004 (SCI İndekslerine Giren Dergi) identifier identifier identifier

Özet

Objectives: Ischemia-reperfusion (I-R) injury induces production of reactive oxygen species (ROS) and some inflammatory mediators like tumor necrosis factor (TNF). We compared the effects of IL-10 and anti IL-12 antibody (Ab) on TNF-alpha production and oxidative stress markers. We also searched for which one, anti IL-12 or IL-10, is superior in the prevention of I-R induced oxidative stress.