Which is more effective in the prevention of renal ischemia-reperfusion-induced oxidative injury in the early period in mice: interleukin (IL)-10 or anti-IL-12?


Koken T., Serteser M., Kahraman A., Akbulut G., Dilek O.

CLINICAL BIOCHEMISTRY, vol.37, no.1, pp.50-55, 2004 (Peer-Reviewed Journal) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 37 Issue: 1
  • Publication Date: 2004
  • Doi Number: 10.1016/j.clinbiochem.2003.10.001
  • Journal Name: CLINICAL BIOCHEMISTRY
  • Journal Indexes: Science Citation Index Expanded
  • Page Numbers: pp.50-55
  • Keywords: ischemia-reperfusion, TNF-alpha, IL-10, anti-IL-12, oxidative stress, TUMOR-NECROSIS-FACTOR, ISCHEMIA/REPERFUSION INJURY, FACTOR-ALPHA, UP-REGULATION, IN-VIVO, ENDOTOXEMIA, FAILURE, CELLS, INVOLVEMENT, INHIBITION

Abstract

Objectives: Ischemia-reperfusion (I-R) injury induces production of reactive oxygen species (ROS) and some inflammatory mediators like tumor necrosis factor (TNF). We compared the effects of IL-10 and anti IL-12 antibody (Ab) on TNF-alpha production and oxidative stress markers. We also searched for which one, anti IL-12 or IL-10, is superior in the prevention of I-R induced oxidative stress.