Which is more effective in the prevention of renal ischemia-reperfusion-induced oxidative injury in the early period in mice: interleukin (IL)-10 or anti-IL-12?

Koken T., Serteser M. , Kahraman A., Akbulut G., Dilek O.

CLINICAL BIOCHEMISTRY, vol.37, no.1, pp.50-55, 2004 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 37 Issue: 1
  • Publication Date: 2004
  • Doi Number: 10.1016/j.clinbiochem.2003.10.001
  • Title of Journal : CLINICAL BIOCHEMISTRY
  • Page Numbers: pp.50-55


Objectives: Ischemia-reperfusion (I-R) injury induces production of reactive oxygen species (ROS) and some inflammatory mediators like tumor necrosis factor (TNF). We compared the effects of IL-10 and anti IL-12 antibody (Ab) on TNF-alpha production and oxidative stress markers. We also searched for which one, anti IL-12 or IL-10, is superior in the prevention of I-R induced oxidative stress.