Does it take three to tango? An unsuspected multimorbidity of CD8<sup>+</sup> T cell lymphoproliferative disorder, malaria, and EBV infection.

Ekemen S., Uzay A. , Bassullu N. , Dikicioglu-Cetin E., Matsuda K., Ince Ü. , ...More

Malaria journal, vol.17, no.1, pp.349, 2018 (Journal Indexed in SCI Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 17 Issue: 1
  • Publication Date: 2018
  • Doi Number: 10.1186/s12936-018-2497-9
  • Title of Journal : Malaria journal
  • Page Numbers: pp.349


Background: Malaria is known to cause acute and deadly complications. However, malaria can cause unforeseen pathologies due to its chronicity. It increases the risk of endemic Burkitt Lymphoma development by inducing DNA damage in germinal centre (GC) B cells, and leading higher frequency of Epstein-Barr virus (EBV)-infected cells in GCs. EBV is well known for its tropism for B cells. However, less is known about EBV's interaction with T cells and its association with T cell lymphoma.