Effect of lidocaine spray in pain management during office-based endometrial sampling: A randomised placebo-controlled trial

Aksoy H., Aksoy U., Ozyurt S., Acmaz G., Babayigit M. A. , Yucel B., ...More

JOURNAL OF OBSTETRICS AND GYNAECOLOGY, vol.36, no.2, pp.246-250, 2016 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 36 Issue: 2
  • Publication Date: 2016
  • Doi Number: 10.3109/01443615.2015.1060201
  • Page Numbers: pp.246-250


Office-based endometrial sampling is the most frequently performed gynaecological procedure. The procedure is usually associated with pain and discomfort. Several anaesthetic and analgesic techniques (e.g., non-steroidal anti-inflammatory drugs, paracervical block, misoprostol and topical anaesthetics) are used for pain management during endometrial sampling. There is no comprehensive study using lidocaine in spray form; we sought to investigate the analgesic efficacy of 10% lidocaine spray in patients undergoing office-based endometrial biopsy. We conducted a prospective, randomised (lidocaine spray (n = 60) and placebo (n = 60), respectively), double-blind study. The mean pain score during procedure was 3.51 +/- 1.51 in the lidocaine spray group and 5.11 +/- 1.66 in the placebo group. Lidocaine spray treatment significantly lowered the pain scores compared with placebo (p < 0.001). Lidocaine spray can be accepted as a non-invasive, easy to apply and more comfortable anaesthetic method for office-based endometrial sampling.