Effect of lidocaine spray in pain management during office-based endometrial sampling: A randomised placebo-controlled trial

Aksoy H., Aksoy U., Ozyurt S., Acmaz G., Babayigit M. A. , Yucel B., ...Daha Fazla

JOURNAL OF OBSTETRICS AND GYNAECOLOGY, cilt.36, sa.2, ss.246-250, 2016 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 36 Konu: 2
  • Basım Tarihi: 2016
  • Doi Numarası: 10.3109/01443615.2015.1060201
  • Sayfa Sayıları: ss.246-250


Office-based endometrial sampling is the most frequently performed gynaecological procedure. The procedure is usually associated with pain and discomfort. Several anaesthetic and analgesic techniques (e.g., non-steroidal anti-inflammatory drugs, paracervical block, misoprostol and topical anaesthetics) are used for pain management during endometrial sampling. There is no comprehensive study using lidocaine in spray form; we sought to investigate the analgesic efficacy of 10% lidocaine spray in patients undergoing office-based endometrial biopsy. We conducted a prospective, randomised (lidocaine spray (n = 60) and placebo (n = 60), respectively), double-blind study. The mean pain score during procedure was 3.51 +/- 1.51 in the lidocaine spray group and 5.11 +/- 1.66 in the placebo group. Lidocaine spray treatment significantly lowered the pain scores compared with placebo (p < 0.001). Lidocaine spray can be accepted as a non-invasive, easy to apply and more comfortable anaesthetic method for office-based endometrial sampling.