DEVELOPMENT OF LIPOSOMAL CARRIER SYSTEMS OF RETINOL AND INVESTIGATION OF THE PENETRATION.


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Uzuner Y. , Sevinç H.

8th BBBB International Conference on Pharmaceutical Sciences, İzmir, Türkiye, 14 - 16 Ekim 2019, ss.291-292

  • Basıldığı Şehir: İzmir
  • Basıldığı Ülke: Türkiye
  • Sayfa Sayıları: ss.291-292

Özet

Liposomes are small vesicles with hydrophilic and hydrophobic parts having an amphipathic structure. They have been used for many years in pharmaceutical, chemical and cosmetic industries as carrier systems because of their many favorable properties such as their structure which simulates the cell membrane, non-toxic properties and ability to carry the molecules selected by the researchers. Liposomes are also practical systems because they can be prepared easily and can encapsulate a variety of active substances[1].

Particle size distribution and diffusion profiles of the liposomes which were prepared by different methods were measured at predetermined intervals to characterize and monitor the stability of them. The diffusion profiles of the actives entrapped in the liposomes, representing the penetration of these actives through the skin barrier, were studied with Franzcell diffusion method and diffused amounts of them were measured by High-Performance Liquid Chromatography (HPLC)[2].

This study showed the use of in-vitro Franzcell diffusion tests as efficacy tests instead of   in-vivo tests which are very difficult tests to perform, and how the liposomes can increase the number of active materials as delivery/carrier systems