Akademik Veri Yönetim Sistemi
8th BBBB International Conference on Pharmaceutical Sciences, İzmir, Türkiye, 14 - 16 Ekim 2019, ss.291-292
Liposomes
are small vesicles with hydrophilic and hydrophobic parts having an amphipathic
structure. They have been used for many years in pharmaceutical, chemical and
cosmetic industries as carrier systems because of their many favorable
properties such as their structure which simulates the cell membrane, non-toxic
properties and ability to carry the molecules selected by the researchers.
Liposomes are also practical systems because they can be prepared easily and
can encapsulate a variety of active substances[1].
Particle size distribution and diffusion profiles of the liposomes
which were prepared by different methods were measured at predetermined
intervals to characterize and monitor the stability of them. The diffusion
profiles of the actives entrapped in the liposomes, representing the
penetration of these actives through the skin barrier, were studied with
Franzcell diffusion method and diffused amounts of them were measured by
High-Performance Liquid Chromatography (HPLC)[2].
This study showed the use of in-vitro
Franzcell diffusion tests as efficacy tests instead of in-vivo
tests which are very difficult tests to perform, and how the liposomes can
increase the number of active materials as delivery/carrier systems