Tryptase potentiates enteric nerve activation by histamine and serotonin: Relevance for the effects of mucosal biopsy supernatants from irritable bowel syndrome patients


Ostertag D., Annahazi A., Krueger D., Michel K., Demir I. E. , Ceyhan G. O. , ...More

NEUROGASTROENTEROLOGY AND MOTILITY, vol.29, no.9, 2017 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 29 Issue: 9
  • Publication Date: 2017
  • Doi Number: 10.1111/nmo.13070
  • Title of Journal : NEUROGASTROENTEROLOGY AND MOTILITY

Abstract

Background: We previously showed that mucosal biopsy supernatants from irritable bowel syndrome patients activated neurons despite low concentrations of tryptase, histamine, and serotonin which individually would not cause spike discharge. We studied the potentiating responses between these mediators on excitability of enteric neurons.