Mortality Risk Factors among Critically Ill Children with Acute COVID-19 in PICUs: A Multicenter Study from Turkish Pediatric Critical COVID-19 and MIS-C Study Group

Akcay, Nihal; Kihtir, Hasan; Durak, Cansu; Kendirli, Tanil; Havan, Merve; Kockuzu, Esra; Bozan, Gurkan; Sevketoglu, Esra; Varol, Fatih; Uyar, Emel; Özçifçi, Gökçen; SIK, SARE; Terzi, Kivanç; Yesilbaş, Osman; Yildizdaş, Dinçer; Akyildiz, Başak; Öztürk, Makbule; Yazar, Abdullah; Yener, Nazik; Petmezci, Mey; Bayraktar, Süleyman; Oto, Arzu; Duyu, Muhterem; Yükselmiş, Ufuk; Kutlu, Nurettin; Altuǧ, Ümüt; Topal, Sevgi; Öztürk, Zeynelabidin; Akkuzu, Emine; Besci, Tolga; Özkaya, Pinar; Durak, Fatih; Aslan, Nagehan; Sandal, Özlem; Ödek, Çaǧlar; Barlas, Ülkem; Çeleǧen, Mehmet; Özkale, Murat; Kangin, Murat; Atay, Gürkan; Çoban, Yasemin; Alaçakir, Nuri; Kamit, Fulya; Yaman, Ayhan; Yetimakman, Ayşe; Sofuoǧlu, Ayşe; Aygün, Fatih; Gurbanov, Anar; Ersoy, Murat; Bozdemir, Şefika; Kiral, Eylem; Şahin, Ebru; Perk, Oktay; Çitak, AGOP; Bayrakçi, Benan; Gayretli Aydin, Zeynep; Ekinci, Faruk; Çetin, Benhur; Girgin, Feyza; Akin, Fatih; Albayrak, Hatice; Boyraz, Merve; Utku, Hatice; Yazici, Mutlu; Arslan, Gazi; Ersayoǧlu, İrem; Birbilen, Ahmet; Soydan, Ekin; Bülbül, Beyhan; Ongun, Ebru; Özkale, Yasemin; Talay, Mehmet; Erdoǧan, Seher; Menentoǧlu, Mehmet; Oǧur, Mustafa; Duman, Murat

doi:10.1097/inf.0000000000003592

Mortality Risk Factors among Critically Ill Children with Acute COVID-19 in PICUs: A Multicenter Study from Turkish Pediatric Critical COVID-19 and MIS-C Study Group

Atıf İçin Kopyala

Akcay N., Kihtir H. S., Durak C., Kendirli T., Havan M., Kockuzu E., ...Daha Fazla

Pediatric Infectious Disease Journal, cilt.41, sa.9, ss.742-750, 2022 (SCI-Expanded)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 41 Sayı: 9
Basım Tarihi: 2022
Doi Numarası: 10.1097/inf.0000000000003592
Dergi Adı: Pediatric Infectious Disease Journal
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, PASCAL, BIOSIS, CAB Abstracts, EMBASE, MEDLINE, Veterinary Science Database
Sayfa Sayıları: ss.742-750
Anahtar Kelimeler: Child, COVID-19, mortality, PICU
Acıbadem Mehmet Ali Aydınlar Üniversitesi Adresli: Evet

Özet

© 2022 Lippincott Williams and Wilkins. All rights reserved.Background: During the coronavirus disease 2019 (COVID-19) pandemic, the world has a large number of reported COVID-19 cases and deaths. Information on characteristics and mortality rate of pediatric intensive care unit (PICU) cases with COVID-19 remains limited. This study aims to identify the risk factors for mortality related to COVID-19 in children admitted to PICU. Methods: A retrospective multicenter cohort study was conducted between March 2020 and April 2021 at 44 PICUs in Turkey. Children who were 1 month-18-year of age with confirmed COVID-19 admitted to PICU were included in the study. Children with multisystem inflammatory syndrome and asymptomatic for COVID-19 were excluded. Results: Of 335 patients with COVID-19, the median age was 6.8 years (IQR: 1.2-14) and 180 (53.7 %) were male, 215 (64.2 %) had at least one comorbidity. Age and gender were not related to mortality. Among 335 patients, 166 (49.5%) received mechanical ventilation, 17 (5.1%) received renal replacement therapy and 44 (13.1 %) died. Children with medical complexity, congenital heart disease, immunosuppression and malignancy had significantly higher mortality. On multivariable logistic regression analysis, organ failure index [odds ratio (OR): 2.1, 95 confidence interval (CI): 1.55-2.85], and having congenital heart disease (OR: 2.65, 95 CI: 1.03-6.80), were associated with mortality. Conclusions: This study presents detailed data on clinical characteristics and outcomes of patients with COVID-19 admitted to PICU in the first pandemic year in Turkey. Our study shows that having congenital heart disease is associated with mortality. In addition, the high organ failure score in follow-up predict mortality.