Treatment with milk thistle extract (Silybum marianum), ursodeoxycholic acid, or their combination attenuates cholestatic liver injury in rats: Role of the hepatic stem cells

ALACA N., ÖZBEYLİ D., Uslu S., Sahin H. H., Yigitturk G., KURTEL H., ...Daha Fazla

TURKISH JOURNAL OF GASTROENTEROLOGY, cilt.28, sa.6, ss.476-484, 2017 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 28 Sayı: 6
  • Basım Tarihi: 2017
  • Doi Numarası: 10.5152/tjg.2017.16742
  • Dergi Adı: TURKISH JOURNAL OF GASTROENTEROLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.476-484
  • Anahtar Kelimeler: Bile duct ligation, milk thistle (Silybum marianum), oxidative stress, primary biliary cirrhosis, stem cell factor, ursodeoxycholic acid, RECEPTOR C-KIT, EXPRESSION, SILYMARIN, REGENERATION, INFLAMMATION, FIBROSIS
  • Acıbadem Mehmet Ali Aydınlar Üniversitesi Adresli: Evet

Özet

Background/Aims: Cholestasis, which results in hepatic cell death, fibrosis, cirrhosis, and eventually liver failure, is associated with oxidative stress. The aim of this study was to evaluate the effects of milk thistle (MT, Silybum marianum) and ursodeoxycholic acid (UDCA) or their combination on the activation of hepatic stem cells and on the severity of cholestasis liver injury in rats.