TURKISH JOURNAL OF GASTROENTEROLOGY, vol.28, no.6, pp.476-484, 2017 (Journal Indexed in SCI)
Article / Article
Title of Journal :
TURKISH JOURNAL OF GASTROENTEROLOGY
Bile duct ligation, milk thistle (Silybum marianum), oxidative stress, primary biliary cirrhosis, stem cell factor, ursodeoxycholic acid, RECEPTOR C-KIT, EXPRESSION, SILYMARIN, REGENERATION, INFLAMMATION, FIBROSIS
Background/Aims: Cholestasis, which results in hepatic cell death, fibrosis, cirrhosis, and eventually liver failure, is associated with oxidative stress. The aim of this study was to evaluate the effects of milk thistle (MT, Silybum marianum) and ursodeoxycholic acid (UDCA) or their combination on the activation of hepatic stem cells and on the severity of cholestasis liver injury in rats.