Treatment with milk thistle extract (Silybum marianum), ursodeoxycholic acid, or their combination attenuates cholestatic liver injury in rats: Role of the hepatic stem cells


Alaca N. , ÖZBEYLİ D., USLU S., Sahin H. H. , YİĞİTTÜRK G., KURTEL H., ...More

TURKISH JOURNAL OF GASTROENTEROLOGY, vol.28, no.6, pp.476-484, 2017 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 28 Issue: 6
  • Publication Date: 2017
  • Doi Number: 10.5152/tjg.2017.16742
  • Title of Journal : TURKISH JOURNAL OF GASTROENTEROLOGY
  • Page Numbers: pp.476-484
  • Keywords: Bile duct ligation, milk thistle (Silybum marianum), oxidative stress, primary biliary cirrhosis, stem cell factor, ursodeoxycholic acid, RECEPTOR C-KIT, EXPRESSION, SILYMARIN, REGENERATION, INFLAMMATION, FIBROSIS

Abstract

Background/Aims: Cholestasis, which results in hepatic cell death, fibrosis, cirrhosis, and eventually liver failure, is associated with oxidative stress. The aim of this study was to evaluate the effects of milk thistle (MT, Silybum marianum) and ursodeoxycholic acid (UDCA) or their combination on the activation of hepatic stem cells and on the severity of cholestasis liver injury in rats.