The relationship between UGT1A4 polymorphism and serum concentration of lamotrigine in patients with epilepsy

Gulcebi, Medine; Ozkaynakci, Aydan; GÖREN, MEHMET; GÜLHAN, REZZAN; ÖZKARA, Çiğdem; Onat, FILIZ

doi:10.1016/j.eplepsyres.2011.01.016

The relationship between UGT1A4 polymorphism and serum concentration of lamotrigine in patients with epilepsy

Gulcebi M. I., Ozkaynakci A., GÖREN M. Z., GÜLHAN R., ÖZKARA Ç., Onat F.

EPILEPSY RESEARCH, cilt.95, ss.1-8, 2011 (SCI-Expanded, Scopus)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 95
Basım Tarihi: 2011
Doi Numarası: 10.1016/j.eplepsyres.2011.01.016
Dergi Adı: EPILEPSY RESEARCH
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.1-8
Anahtar Kelimeler: Lamotrigine, Genetic polymorphism, Glucuronidation, Pharmacogenomics, Pharmacotherapy, ANTIEPILEPTIC DRUGS, GLUCURONIDATION, PHARMACOKINETICS, PREGNANCY, POPULATION, PLASMA
Acıbadem Mehmet Ali Aydınlar Üniversitesi Adresli: Hayır

Özet

Lamotrigine (LTG) which has a widespread use in epilepsy treatment as an antiepileptic agent is metabolized by UDP-glucuronosyl transferase (UGT) enzymes. In this study, single nucleotide polymorphisms, P24T and L48V, of the UGT1A4 enzyme have been investigated in a Turkish population of patients with epilepsy (n=131) by comparing serum levels of LTG of wild type and polymorphic subjects.