Gas what! NO Is not the only answer for sexual functıon

Anacak G. Y.

27. Ulusal, 2. Uluslararası Farmakoloji Kongresi, Antalya, Türkiye, 23 - 26 Kasım 2023, ss.14-15

  • Yayın Türü: Bildiri / Özet Bildiri
  • Basıldığı Şehir: Antalya
  • Basıldığı Ülke: Türkiye
  • Sayfa Sayıları: ss.14-15
  • Acıbadem Mehmet Ali Aydınlar Üniversitesi Adresli: Evet

Özet

TFD2023 kongresi “Recent Advances in Andrology Research” panel

Gas what: NO is not the only answer to sexual function

Gunay Yetik-Anacak, Prof.

Acibadem Mehmet Ali Aydinlar University, Faculty of Pharmacy, Department of Pharmacology

Istanbul-Turkiye


Erectile physiology is interplay of vascular, neurologic and endocrine factors leading to increase or facilitate the vasodilation (tumescence) and/or reduce the contraction (detumescence) of the corpus cavernosum smooth muscle (CCSM) cells. Deficiency in any or all of these systems results in erectile dysfunction. Erectile dysfunction (ED) is defined as “a man's persistent or recurring inability to achieve and/or maintain a penile erection sufficient for sexual performance” (1). The risk of ED increases with age (2). ED of organic origin is usually caused by hormonal, hemodynamic, neurological or vascular pathologies.

ED started to be accepted as an early indicator for systemic endothelial dysfunction and subsequent of cardiovascular diseases (3). The role of nitric oxide (NO) in endothelial relaxation and erectile function is well accepted. The discovery of NO as small signaling gasotransmitter led to investigate the role of other endogenously derived gases; carbon monoxide (CO) and hydrogen sulfide (H2S) in physiological and pathophysiological conditions. The role of NO and CO in sexual function and dysfunction has been investigated more extensively and the involvement of H2S in the erectile function has also been confirmed.

The role of soluble guanylyl cyclase /cyclic GMP pathway is a common target of these 3 gasotransmitters. Several studies proposed alternative therapies targeting different mechanisms additional to phosphodiesterase-5 inhibition for ED treatment, since there are patients not responding to these drugs. Therefore these mediators are complementary and possibly coordinated physiologic roles in erectile function and treatments targeting these gasotransmitters in ED are required. When “NO” is not enough, the other sister gases may assist sexual function in representing potentials, as a new therapeutic targets for ED.