Glycemic Variability Promotes Both Local Invasion and Metastatic Colonization by Pancreatic Ductal Adenocarcinoma

Jian Z., Cheng T., Zhang Z., Raulefs S., Shi K., Steiger K., ...Daha Fazla

CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY, cilt.6, sa.4, ss.429-449, 2018 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 6 Sayı: 4
  • Basım Tarihi: 2018
  • Doi Numarası: 10.1016/j.jcmgh.2018.07.003
  • Dergi Adı: CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.429-449
  • Anahtar Kelimeler: Pancreatic Cancer, Glucose Metabolism, Metastasis, Retinoic Acid, DIABETES-MELLITUS, METFORMIN USE, CANCER, SURVIVAL, RESECTION, IMPACT, RISK, METABOLISM, MUTATIONS, PATTERNS
  • Acıbadem Mehmet Ali Aydınlar Üniversitesi Adresli: Hayır

Özet

BACKGROUND & AIMS: Although nearly half of pancreatic ductal adenocarcinoma (PDAC) patients have diabetes mellitus with episodes of hyperglycemia, its tumor microenvironment is hypoglycemic. Thus, it is crucial for PDAC cells to develop adaptive mechanisms dealing with oscillating glucose levels. So far, the biological impact of such glycemic variability on PDAC biology remains unknown.