Relationship between serum sialic acid levels and prolidase activity with airflow obstruction in patients with COPD


UYSAL P., Teksoz D., Aksan H., DURMUŞ S., Uslu-Besli L., ÇUHADAROĞLU Ç., ...Daha Fazla

Medicine (United States), cilt.101, sa.11, 2022 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Derleme
  • Cilt numarası: 101 Sayı: 11
  • Basım Tarihi: 2022
  • Doi Numarası: 10.1097/md.0000000000028949
  • Dergi Adı: Medicine (United States)
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, BIOSIS, CAB Abstracts, CINAHL, EMBASE, MEDLINE, Veterinary Science Database, Directory of Open Access Journals
  • Anahtar Kelimeler: C-reactive protein, chronic obstructive pulmonary disease, prolidase activity, sialic acid
  • Acıbadem Mehmet Ali Aydınlar Üniversitesi Adresli: Evet

Özet

© 2022 Lippincott Williams and Wilkins. All rights reserved.Our aim in this study was to evaluate the prognostic significance of sialic acid (SA) and prolidase activity and to evaluate the association between airflow obstruction severity and these parameters in chronic obstructive pulmonary disease (COPD) patients. Ninety-four patients (84 M, 10 F) and 34 healthy subjects (19 M, 15 F) were included into the study. COPD staging was performed to COPD patients according to new global initiative for chronic obstructive lung disease criteria which includes pulmonary function tests, symptoms and hospitalization; COPD patients were divided into 4 subgroups as group A (n = 25), group B (n = 19), group C (n = 20), and group D (n = 28). SA and C-reactive protein levels were significantly higher than the control group in all COPD groups. SA levels were significantly higher in group B patients than the control and group A. Prolidase activity was significantly lower than control group in total COPD groups (P <.05). There was a weak negative correlation between SA and forced vital capacity (r = -0.217, P =.038) and forced expiratory volume in 1 second (FEV1) (r = -0.210, P =.045), whereas weak positive correlation was present between SA and Creactive protein (r = 0.247, P =.018) in all patient groups. There was weak positive correlation between prolidase and FEV1 (r = 0.222, P =.033) and FEV1/forced vital capacity (r = 0.230, P =.027). Our study shows that systemic inflammation, prolidase activity, and SA levels in stable COPD patients are associated with airflow obstruction severity. In addition to the prolidase activity; SA levels might be associated with inflammation.