Dendron-polymer conjugates via the diels-alder "click" reaction of novel anthracene-based dendrons

Gok Ö., Yigit S., Kose M. M., Sanyal R., Sanyal A.

JOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY, cilt.51, sa.15, ss.3191-3201, 2013 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 51 Sayı: 15
  • Basım Tarihi: 2013
  • Doi Numarası: 10.1002/pola.26708
  • Dergi Adı: JOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.3191-3201
  • Anahtar Kelimeler: anthracene, block copolymers, click cycloaddition, dendrimers, dendronized polymers, Diels-Alder polymers, MULTIARM STAR POLYMERS, THIOL-ENE CLICK, SURFACE FUNCTIONALIZATION, DENDRITIC POLYMERS, DRUG, DELIVERY, THERAPEUTICS, PEGYLATION, CHEMISTRY, HYDROGELS
  • Acıbadem Mehmet Ali Aydınlar Üniversitesi Adresli: Hayır

Özet

Diblock and triblock dendron-polymer conjugates containing biodegradable polyester dendron blocks and polyethylene glycol (PEG) polymer were synthesized using the Diels-Alder click cycloaddition reaction. PEG polymers with furan-protected maleimide functionality were synthesized and reacted with biodegradable polyester dendrons containing an anthracene moiety at their focal point. First through third generations of biodegradable polyester dendrons containing an anthracene unit at their focal point were synthesized using a divergent strategy. Efficient conjugation of the dendrons to polymers was demonstrated using 1HNMR and size exclusion chromatography. This modular approach provides an easy access to the design of multivalent PEG conjugates. (c) 2013 Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem. 2013, 51, 3191-3201