Is Endometrial Receptivity Assay (ERA) Useful in Patients with Repeated Implantation Failure Undergoing Single, Autologous Euploid Embryo Transfer?

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ÖZALTIN S., Celik H. G. , TAKMAZ Ö., Yagmur E., ÖZBAŞLI E., GÜNGÖR M., ...More

CLINICAL AND EXPERIMENTAL OBSTETRICS & GYNECOLOGY, vol.49, no.9, 2022 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 49 Issue: 9
  • Publication Date: 2022
  • Doi Number: 10.31083/j.ceog4909198
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, EMBASE, Directory of Open Access Journals
  • Keywords: endometrial receptivity assay (ERA), intracytoplasmic sperm injection (ICSI), in vitro fertilization (IVF), repeated implan-tation failure (RIF), window of implantation, LIVE BIRTH, BIOPSY, ANEUPLOIDY, INTEGRINS, WOMEN
  • Acibadem Mehmet Ali Aydinlar University Affiliated: Yes


Background: Our aim in this study was to evaluate whether endometrial receptivity assay (ERA) test improves single, autologous euploid frozen-thawed embryo transfer (FET) outcomes in patients with repeated implantation failure. Methods: This was a retrospective cohort study which was conducted in a University affiliated private hospital. The study included 135 patients with repeated implantation failure who underwent single, autologous euploid ERA adjusted and non-adjusted FET. Patients were stratified into three groups, patients with receptive endometrium based on the ERA test, patients with non-receptive endometrium based on the ERA test and patients who did not receive the ERA test (control group). The three groups were compared in terms of FET outcomes. Results: Of 135 patients, 73 had the ERA test results available and 62 did not have the ERA test. Of 73 patients, 28 had non-receptive endometrium and 45 had receptive endometrium. The three groups are all the same in terms of age, body mass index, type of infertility, duration of infertility, number of previously embryo transfers and infertility causes (p > 0.05). Live birth rates were 46%, 50% and 51% for receptive, nonreceptive and control groups, respectively (p > 0.05). Implantation and clinical pregnancy rates were similar between the groups, as well. Conclusions: Adjusting the embryo transfer day according to the ERA test results seems to improve FET outcomes in patients with repeated implantation failure.