Akademik Veri Yönetim Sistemi
ENDOCRINOLOGIST, cilt.18, sa.5, ss.238-240, 2008 (SCI-Expanded)
The objective of this study is to evaluate the possible effect of thyroid palpation and fine needle aspiration biopsy on serum thyroid hormones and thyroglobulin in patients with several thyroid diseases. We measured serum free T4. free T3, TSH, and thyroglobulin levels at baseline, 5 and 60 minutes in 13 normal control subjects (group 1). These parameters were next measured at baseline. after 5 and 60 minutes vigorous palpation of the thyroid in 11 normal subjects without any thyroid disease (group 2), and in 61 patients with various thyroid diseases (group 3). We also measured the same parameters at baseline, after 5 and 60 minutes of fine needle aspiration biopsy in 13 patients with euthyroid nodular goiter (group 4). Serum free T4, free T3, TSH, and thyroglobulin levels were not changed after 5 minutes in any group. Serum TSH level was decreased after 60 minutes of thyroid palpation (P = 0.01) in group 2. Serum free T4, free T3, and thyro-lobulin levels were not significantly different in these subjects. Serum free T4 (P =0.01) and TSH levels (P = 0.01) were decreased after 60 minutes of thyroid palpation in group 3. Serum TSH level was decreased (P = 0.02). Thyroglobulin level was increased 60 minutes after fine needle aspiration biopsy in group 4 (P = 0.04). There was no correlation between thyroid volume and change of serum TSH, free T3, free T4. and thyroglobulin levels. Our results suggest that fine needle aspiration results in a significant increase in serum thyroglobulin 60 minutes after the procedure. Palpation and fine needle aspiration have no clinical significant effects on TSH, free T4, or free T3 levels.