Expression profiles of 151 pediatric low-grade gliomas reveal molecular differences associated with location and histological subtype

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Bergthold G., Bandopadhayay P., Hoshida Y., Ramkissoon S., Ramkissoon L., Rich B., ...Daha Fazla

NEURO-ONCOLOGY, cilt.17, sa.11, ss.1486-1496, 2015 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 17 Sayı: 11
  • Basım Tarihi: 2015
  • Doi Numarası: 10.1093/neuonc/nov045
  • Dergi Adı: NEURO-ONCOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1486-1496
  • Anahtar Kelimeler: BRAF duplication, BRAF mutation, expression, heterogeneity, pediatric low-grade glioma, GENE-EXPRESSION, PILOCYTIC ASTROCYTOMAS, OPTIC PATHWAY, CANCER, DUPLICATION, RECURRENT, PHOSPHORYLATION, CLASSIFICATION, HETEROGENEITY, ACTIVATION
  • Acıbadem Mehmet Ali Aydınlar Üniversitesi Adresli: Evet

Özet

Pediatric low-grade gliomas (PLGGs), the most frequent pediatric brain tumor, comprise a heterogeneous group of diseases. Recent genomic analyses suggest that these tumors are mostly driven by mitogene-activated protein kinase (MAPK) pathway alterations. However, little is known about the molecular characteristics inherent to their clinical and histological heterogeneity.