The Investigation of the Heavy Atom, Extended Π-Conjugation, and Axial Group Effect on Photoproperties and Formulation of Phthalocyanines and Naphthalocyanines

Emamı A., Özdemir B., Harmandar K., İşçi Ü., Cammas-Marion S., Dumoulin F., ...Daha Fazla

19th Asian Chemical Congress, İstanbul, Türkiye, 9 - 14 Temmuz 2023, ss.179-180, (Özet Bildiri)

  • Yayın Türü: Bildiri / Özet Bildiri
  • Basıldığı Şehir: İstanbul
  • Basıldığı Ülke: Türkiye
  • Sayfa Sayıları: ss.179-180
  • Acıbadem Mehmet Ali Aydınlar Üniversitesi Adresli: Evet

Özet

The Investigation of the Heavy Atom, Extended Π-Conjugation, and Axial Group Effect on Photoproperties and Formulation of Phthalocyanines and Naphthalocyanines Atefeh Emami1 , Burak Özdemir1 , Kevser Harmandar2 , Devrim Atilla3 , Ümit Işçi3 , Sandrine Cammas Marion4 , Fabienne Dumoulin5 , Emel Önal6

Owing to their extraordinary photoproperties, phthalocyanines are excellent photosensitisers for anti-cancer photodynamic therapy [1-2]. The undesired tendency of phthalocyanines to aggregate can be limited by using axial substituents that can be inserted on some metals and semi-metals, such as Si and Ru. In order to compare three structural parameters, a full series of phthalocyanines have been designed:

1. Preparation of Si / Ru phthalocyanine derivatives for the examination of the impact of heavy atoms on their fluorescence and singlet oxygen generation ability. 2. Synthesis of phthalocyanine and naphthalocyanine structures for the investigation of the enhanced electronic delocalization on the red-shifting of their maximum absorption. 3. Use of small and bulky axial substituent for the modulation of their aggregation. As these phthalocyanines are hydrophobic, they have been encapsulated into poly(malic acid) based nanoparticles for increasing solubility in water and improving their photophysico-chemical properties.

The Scientific and Technological Research Council of Türkiye (TUBITAK) and the French Embassy in Türkiye are gratefully acknowledged for the bilateral Partenariat Hubert Curien between Türkiye and France (project Bosphorus 120N684/4665SH).

References:

[1] P.-C. Lo, M. S. Rodríguez-Morgade, R. K. Pandey, D. K. P. Ng, T. Torres and F. Dumoulin, Chem. Soc. Rev. 2020, 49, 1041-1056.

[2] Z. S. Topal, Ü. İşci, U. Kumru, D. Atilla, A. G. Gürek, C. Hirel, M. Durmuş, J-B Tommasino, D. Luneau, S. Berber, F. Dumoulin and V. Ahsen, Dalton Trans. 2014, 43, 6897-6908. Keywords: Phthalocyanines, Heavy atom effect, Aggregation, Singlet oxygen generation, Encapsulation