The effect of femoral nerve block on fracture healing via expressions of growth factors and β-catenin.

Creative Commons License

Uslu S., Irban A. G., GERELI A., AYDINLAR E., Elpen P., İNCE Ü.

Folia histochemica et cytobiologica, cilt.54, sa.3, ss.151-158, 2016 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 54 Sayı: 3
  • Basım Tarihi: 2016
  • Doi Numarası: 10.5603/fhc.a2016.0017
  • Dergi Adı: Folia histochemica et cytobiologica
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.151-158
  • Anahtar Kelimeler: fracture healing, TGF-beta, VEGF, beta-catenin, histomorphometry, femoral nerve block, rat, TOTAL KNEE ARTHROPLASTY, TOTAL HIP-ARTHROPLASTY, AMBULATORY SURGERY, MOLECULAR ASPECTS, BONE-FORMATION, RAT MODEL, REPAIR, CALLUS, ANGIOGENESIS, ANALGESIA
  • Acıbadem Mehmet Ali Aydınlar Üniversitesi Adresli: Evet

Özet

Introduction. Many patients of all ages are admitted to hospital due to bone fractures. The etiology of fracture has a very wide spectrum, ranging from motor accidents to pathological conditions such as tumors, osteoporosis, and others. Bone fracture healing is a well-programmed and well-organized process, but is also long and intractable. The outcome of this process is therefore affected by many factors, such as the patient's age, ethnicity, nutritional status, and extent of the fracture. At present, regional analgesic techniques are frequently applied in order to avoid the complications of systemic opioid administration, central block applications. Femoral block is one of the regional analgesic techniques frequently applied by anesthesiologists when the lower extremities are involved. In this study, we evaluated the effect of femoral nerve block on the healing of an experimental non-stabilized femur fracture via expression of TGF-beta, VEGF, and beta-catenin and bone histomorphometry in rats.