The importance of histological patterns on PD-L1 staining heterogeneity: Should we use pattern-based approach for selecting tumor samples for PD-L1 testing in lung adenocarcinomas?

Bulutay P., Firat P., Zeren H., Erus S., Tanju S., Dilege S.

Turkish journal of medical sciences, cilt.51, sa.1, ss.204-213, 2021 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 51 Sayı: 1
  • Basım Tarihi: 2021
  • Doi Numarası: 10.3906/sag-2004-61
  • Dergi Adı: Turkish journal of medical sciences
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, CAB Abstracts, EMBASE, MEDLINE, Veterinary Science Database, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.204-213
  • Anahtar Kelimeler: PD-L1, lung cancer, immunotherapy, lung adenocarcinoma, IMMUNE CELLS, EXPRESSION, CANCER, IMMUNOHISTOCHEMISTRY, CLASSIFICATION, IMMUNOTHERAPY, RELIABILITY, ANTI-PD-1, LIGANDS
  • Acıbadem Mehmet Ali Aydınlar Üniversitesi Adresli: Evet

Özet

Background/aim: Programmed death ligand-1 (PD-L1) is a predictive marker for immunotherapeutic agents. However, heterogeneous staining of PD-L1 can cause false-negative results. The aim of this study is to evaluate the importance of histological patterns on PD-L1 staining heterogeneity in lung adenocarcinomas (LAC).