Nerve growth factor & TrkA as novel therapeutic targets in cancer


Demir I. E., Tieftrunk E., Schorn S., Friess H., Ceyhan G. O.

BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER, cilt.1866, sa.1, ss.37-50, 2016 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Derleme
  • Cilt numarası: 1866 Sayı: 1
  • Basım Tarihi: 2016
  • Doi Numarası: 10.1016/j.bbcan.2016.05.003
  • Dergi Adı: BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.37-50
  • Anahtar Kelimeler: NGF, TrkA, p75NTR, Cancer, Growth, Pain, Gene fusion, Gene rearrangement, Monoclonal antibodies, Microenvironment, Nerves, Therapeutic target, P75 NEUROTROPHIN RECEPTOR, PANCREATIC DUCTAL ADENOCARCINOMA, HEPATOCELLULAR-CARCINOMA CELLS, TUMOR-INITIATING CELLS, HUMAN BREAST-CANCER, INDUCED BONE PAIN, HUMAN LUNG-CANCER, PHASE-III TRIAL, PROSTATE-CANCER, PERINEURAL INVASION
  • Acıbadem Mehmet Ali Aydınlar Üniversitesi Adresli: Hayır

Özet

In the past 20 years, nerve growth factor (NGF) and its receptors TrkA & p75NTR were recognized to be overexpressed in the overwhelming majority of human solid cancers. Recent studies discovered the presence of overactive TrkA signaling due to TrkA rearrangements or TrkA fusion products in frequent cancers like colorectal cancer, thyroid cancer, or acute myeloid leukemia. Thus, targeting TrkA/NGF via selective small-molecule-inhibitors or antibodies has gained enormous attention in the drug discovery sector. Clinical studies on the anticancer impact of NGF-blocking antibodies are likely to be accelerated after the recent removal of clinical holds on these agents by regulatory authorities. Based on these current developments, the present review provides not only a broad overview of the biological effects of NGF-TrkA-p75NTR on cancer cells and their microenvironment, but also explains why NGF and its receptors are going to evoke major interest as promising therapeutic anti-cancer targets in the coming decade. (C) 2016 Published by Elsevier B.V.