IL-1 beta is induced in reactive astrocytes in the somatosensory cortex of rats with genetic absence epilepsy at the onset of spike-and-wave discharges, and contributes to their occurrence

Akin, Demet; Ravizza, Teresa; Maroso, Mattia; ÇARÇAK YILMAZ, Nihan; Eryigit, Tugba; Vanzulli, Ilaria; GÜLHAN, REZZAN; Vezzani, Annamaria; Onat, FILIZ

doi:10.1016/j.nbd.2011.05.015

IL-1 beta is induced in reactive astrocytes in the somatosensory cortex of rats with genetic absence epilepsy at the onset of spike-and-wave discharges, and contributes to their occurrence

Akin D., Ravizza T., Maroso M., ÇARÇAK YILMAZ N., Eryigit T., Vanzulli I., ...Daha Fazla

NEUROBIOLOGY OF DISEASE, cilt.44, sa.3, ss.259-269, 2011 (SCI-Expanded, Scopus)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 44 Sayı: 3
Basım Tarihi: 2011
Doi Numarası: 10.1016/j.nbd.2011.05.015
Dergi Adı: NEUROBIOLOGY OF DISEASE
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.259-269
Anahtar Kelimeler: Inflammation, Absence seizures, Interleukins, SWD, EXPERIMENTAL FEBRILE SEIZURES, STATUS EPILEPTICUS, GLUTAMATE UPTAKE, EPILEPTOGENESIS, EXPRESSION, MODEL, ACTIVATION, INTERLEUKIN-1-BETA, HIPPOCAMPUS, CYTOKINES
Acıbadem Mehmet Ali Aydınlar Üniversitesi Adresli: Hayır

Özet

Interleukin (IL)-1 beta plays a crucial role in the mechanisms of limbic seizures in rodent models of temporal lobe epilepsy. We addressed whether activation of the IL-1 beta signaling occurs in rats with genetic absence epilepsy (GAERS) during the development of spike-and-wave discharges (SWDs). Moreover, we studied whether inhibition of IL-1 beta biosynthesis in GAERS could affect SWD activity.