The Role of Rho/Rho-Kinase Pathway in the Pathophysiology of Absence Epilepsy

Carcak N., Yavuz M., Eryigit T., Kurt A. H., Urhan Kucuk M., Onat F., ...Daha Fazla

EPILEPSI, cilt.25, sa.1, ss.1-7, 2019 (ESCI) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 25 Sayı: 1
  • Basım Tarihi: 2019
  • Doi Numarası: 10.14744/epilepsi.2018.30592
  • Dergi Adı: EPILEPSI
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.1-7
  • Anahtar Kelimeler: Absence epilepsy, enzyme-linked immunosorbent assay, Rho/Rho-kinase, Rho-kinase, genetic absence epilepsy rats from Strasburg, Y-27632, KAPPA-B INHIBITION, RHO-KINASE, SOMATOSENSORY CORTEX, NETWORK MECHANISMS, CORTICAL-NEURONS, WAVE DISCHARGES, ROCK INHIBITOR, VALPROIC ACID, GENETIC MODEL, RAT MODEL
  • Acıbadem Mehmet Ali Aydınlar Üniversitesi Adresli: Hayır

Özet

Objectives: Rho/Rho-kinase (ROCK) signaling has been shown to contribute to neuroinflammation, epileptogenesis, and seizures in convulsive-type epilepsy models. However, this pathway has not been investigated in the pathophysiology of absence epilepsy. The aim of this study was to investigate ROCK activity in brain regions involved in spike-and-wave discharge (SWD) generation and the effects of the Rho-kinase inhibitor, Y-27632, on ROCK activity in genetic absence epilepsy rats from Strasburg (GAERS).