8-Hydroxydeoxyguanosine as a Useful Marker for Determining the Severity of Trichloroethylene Exposure

Abusoglu S., Celik H. T., Tutkun E., Yilmaz H., SERDAR M. A., Bal C. D., ...Daha Fazla

ARCHIVES OF ENVIRONMENTAL & OCCUPATIONAL HEALTH, cilt.69, sa.3, ss.180-186, 2014 (SCI-Expanded) identifier identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 69 Sayı: 3
  • Basım Tarihi: 2014
  • Doi Numarası: 10.1080/19338244.2013.763761
  • Dergi Adı: ARCHIVES OF ENVIRONMENTAL & OCCUPATIONAL HEALTH
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.180-186
  • Anahtar Kelimeler: oxidative stress, severity, trichloroacetic acid, workers, OXIDATIVE STRESS, WORKERS, DAMAGE, MICE
  • Acıbadem Mehmet Ali Aydınlar Üniversitesi Adresli: Evet

Özet

The aim of this study was to determine 8-hydroxydeoxyguanosine (8-OH-dG) levels in trichloroethylene (TCE)-exposed workers. Oxidative stress biomarkers and biochemical parameters were monitored among 26 TCE-exposed workers and 78 age-matched control subjects. Levels of urinary 8-OH-dG were analyzed by liquid chromatography tandem mass spectrometry. Urinary 8-OH-dG levels were significantly higher for TCE-exposed group (p < .001). Spearman's correlation test revealed positive correlations between urinary trichloroacetic acid levels and age, urinary 8-OH-dG, urinary total oxidant status, and urinary total antioxidant status (p = .042, p < .001, p < .001, and p < .001, respectively). 8-OH-dG may be a useful marker to determine the extent of TCE exposure.