Biological variations of ADAMTS13 and von Willebrand factor in human adults

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KILERCIK M., COSKUN A., SERTESER M., İNAN D., Unsal I.

BIOCHEMIA MEDICA, cilt.24, sa.1, ss.138-145, 2014 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 24 Sayı: 1
  • Basım Tarihi: 2014
  • Doi Numarası: 10.11613/bm.2014.015
  • Dergi Adı: BIOCHEMIA MEDICA
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.138-145
  • Anahtar Kelimeler: ADAMTS13, variation analysis, individuality, thrombotic thrombocytopenic purpura, von Willebrand factor, THROMBOTIC THROMBOCYTOPENIC PURPURA, INDIVIDUALS
  • Acıbadem Mehmet Ali Aydınlar Üniversitesi Adresli: Evet

Özet

Background: The ultra-large von Willebrand factor (vWF) multimers are very active and must be degraded by ADAMTS13 for optimal activity. A severe functional deficiency of ADAMTS13 has been associated with thrombotic thrombocytopenic purpura. The correct interpretation of patient vWF and ADAMTS13 plasma levels requires an understanding of the biological variation associated with these analytes. In the present paper, we aimed to determine the biological variation of ADAMTS13 and vWF in human adults.