Utility of the Repeat and Point Test for Subtyping Patients With Primary Progressive Aphasia.

Seckin M., Ricard I., Raiser T., Heitkamp N., Ebert A., Prix C., ...Daha Fazla

Alzheimer disease and associated disorders, cilt.36, ss.44-51, 2022 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 36
  • Basım Tarihi: 2022
  • Doi Numarası: 10.1097/wad.0000000000000482
  • Dergi Adı: Alzheimer disease and associated disorders
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, PASCAL, AgeLine, CAB Abstracts, CINAHL, EMBASE, MEDLINE, Psycinfo, Veterinary Science Database
  • Sayfa Sayıları: ss.44-51
  • Anahtar Kelimeler: primary progressive aphasia, single-word comprehension, repetition, agrammatism, classification, SHORT-TERM-MEMORY, SEMANTIC DEMENTIA, FRONTOTEMPORAL PATHOLOGY, LANGUAGE IMPAIRMENTS, ALZHEIMERS-DISEASE, LOGOPENIC VARIANT, CLASSIFICATION, REPETITION, SPEECH, APRAXIA
  • Acıbadem Mehmet Ali Aydınlar Üniversitesi Adresli: Hayır

Özet

Background: Primary progressive aphasia (PPA) may present with three distinct clinical sybtypes: semantic variant PPA (svPPA), nonfluent/agrammatic variant PPA (nfvPPA), and logopenic variant PPA (lvPPA). Objective: The aim was to examine the utility of the German version of the Repeat and Point (R&P) Test for subtyping patients with PPA. Method: During the R&P Test, the examiner reads out aloud a noun and the participants are asked to repeat the word and subsequently point to the corresponding picture. Data from 204 patients (68 svPPA, 85 nfvPPA, and 51 lvPPA) and 33 healthy controls were analyzed. Results: Controls completed both tasks with >90% accuracy. Patients with svPPA had high scores in repetition (mean=9.2 +/- 1.32) but low scores in pointing (mean=6 +/- 2.52). In contrast, patients with nfvPPA and lvPPA performed comparably in both tasks with lower scores in repetition (mean=7.4 +/- 2.7 for nfvPPA and 8.2 +/- 2.34 for lvPPA) but higher scores in pointing (mean=8.9 +/- 1.41 for nfvPPA and 8.6 +/- 1.62 for lvPPA). The R&P Test had high accuracy discriminating svPPA from nfvPPA (83% accuracy) and lvPPA (79% accuracy). However, there was low accuracy discriminating nfvPPA from lvPPA (<60%). Conclusion: The R&P Test helps to differentiate svPPA from 2 nonsemantic variants (nfvPPA and lvPPA). However, additional tests are required for the differentiation of nfvPPA and lvPPA.