A developmental study of glutamatergic neuron populations in the ventrobasal and the lateral geniculate nucleus of the thalamus: Comparing Genetic Absence Rats from Strasbourg (GAERS) and normal control wistar rats

Kirazhi, Ozlem; Caydar, Safiye; Yildizel, Sercan; ONAT, FILIZ; Kaptanoglu, Erkan

doi:10.1016/j.ijdevneu.2016.12.001

A developmental study of glutamatergic neuron populations in the ventrobasal and the lateral geniculate nucleus of the thalamus: Comparing Genetic Absence Rats from Strasbourg (GAERS) and normal control wistar rats

Kirazhi O., Caydar S., Yildizel S., ONAT F., Kaptanoglu E.

INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE, cilt.56, ss.35-41, 2017 (SCI-Expanded, Scopus)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 56
Basım Tarihi: 2017
Doi Numarası: 10.1016/j.ijdevneu.2016.12.001
Dergi Adı: INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.35-41
Acıbadem Mehmet Ali Aydınlar Üniversitesi Adresli: Hayır

Özet

An imbalance of GABAergic inhibition and glutamatergic excitation is suspected to be the cause of absence epileptic seizures. Absence seizures are known to be generated in thalamocortical circuitry. In the present study we used light microscopy immunohistochemistry to quantify the density of glutamate+ve neurons at two developmental stages (P10 and P60) in two thalamic nuclei, the ventrobasal (VB) and lateral geniculate nucleus (LGN) in Wistar rats and compared the results with similar data obtained from genetic absence epilepsy rats from Strasbourg (GAERS).