Chemical composition of endemic<i> Hypericum</i><i> bilgehan-bilgilii</i> Basköse & Savran essential oil and its α-glucosidase antidiabetic, anti-inflammatory, cytotoxic and antioxidant potentials
TRAKYA UNIVERSITY JOURNAL OF NATURAL SCIENCES, cilt.26, sa.2, ss.127-134, 2025 (ESCI, Scopus, TRDizin)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 26 Sayı: 2
- Basım Tarihi: 2025
- Doi Numarası: 10.23902/trkjnat.5767632345
- Dergi Adı: TRAKYA UNIVERSITY JOURNAL OF NATURAL SCIENCES
- Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus, TR DİZİN (ULAKBİM)
- Sayfa Sayıları: ss.127-134
- Acıbadem Mehmet Ali Aydınlar Üniversitesi Adresli: Evet
Özet
Hypericum L. is a significantly important genus for flora of T & uuml;rkiye due to its richness in phytochemicals possessing medicinal and cosmetic benefits. The essential oil composition and biological activities of Hypericum bilgehan-bilgilii Bask & ouml;se & Savran (HEO) were analysed for the first time in the present study. The volatile oil of the whole parts of H. bilgehan-bilgilii was obtained by hydrodistillation with Clevenger-type apparatus. The chemical composition was analyzed by GC-MS using non-polar column. alpha-glucosidase and 5-lipoxygenase inhibitory, cytotoxic, and DPPH radical scavenging activities were investigated. Forty-eight components were identified and represented 97.3% of the whole constituents. Interestingly, the major volatiles: 1-(2,4,5-trimethoxyphenyl)butan-1-one (27.7%) and 3-Methyl-1-(2,4,6-trihydroxyphenyl)butan-1-one (11.2%) were detected for the first time in Hypericum essential oils. The oil exhibited a significant activity against the 5-lipoxygenase enzyme with an IC50 value of 39 mu g/mL. Cytotoxicity potential of HEO was investigated, at different concentrations, towards four cell lines and, IC50 values underlies mild cytotoxicity. These results indicated that H. bilgehan-bilgilii essential oil may be considered as a valuable source for bioactive ingredients and anti-inflammatory agents.