Neuroimaging of neuronal circuits involved in tic generation in patients with Tourette syndrome

Lerner A., Bagic A., Boudreau E. A. , Hanakawa T., Pagan F., Mari Z., ...More

NEUROLOGY, vol.68, no.23, pp.1979-1987, 2007 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 68 Issue: 23
  • Publication Date: 2007
  • Doi Number: 10.1212/01.wnl.0000264417.18604.12
  • Title of Journal : NEUROLOGY
  • Page Numbers: pp.1979-1987


Objective: To identify brain regions generating tics in patients with Tourette syndrome using sleep as a baseline. Methods: We used [O-15]H2O PET to study nine patients with Tourette syndrome and nine matched control subjects. For patients, conditions included tic release states and sleep stage 2; and for control subjects, rest states and sleep stage 2. Results: Our study showed robust activation of cerebellum, insula, thalamus, and putamen during tic release. Conclusion: The network of structures involved in tics includes the activated regions and motor cortex. The prominent involvement of cerebellum and insula suggest their involvement in tic initiation and execution.