VITAMIN D DEFICIENCY DID NOT AUGMENT THE PROGRESSION OF HIGH-FRUCTOSE-INDUCED NONALCOHOLIC FATTY LIVER DISEASE IN RATS

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BİNGÜL İ., KÜÇÜKGERGİN C., AYDIN A. F., Ekici I. D., Abbasoglu S. D., Uysal M.

JOURNAL OF ISTANBUL FACULTY OF MEDICINE-ISTANBUL TIP FAKULTESI DERGISI, cilt.84, sa.3, ss.360-368, 2021 (ESCI) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 84 Sayı: 3
  • Basım Tarihi: 2021
  • Doi Numarası: 10.26650/iuitfd.2021.849531
  • Dergi Adı: JOURNAL OF ISTANBUL FACULTY OF MEDICINE-ISTANBUL TIP FAKULTESI DERGISI
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.360-368
  • Anahtar Kelimeler: Vitamin D deficiency, high fructose diet, nonalcoholic liver disease, glycooxidative stress, antioxidant, inflammation, GLYCATION END-PRODUCTS, OXIDATIVE STRESS, INSULIN-RESISTANCE, INFLAMMATION, FIBROSIS, MODELS
  • Acıbadem Mehmet Ali Aydınlar Üniversitesi Adresli: Evet

Özet

Objective: Vitamin D has antioxidant, anti-inflammatory and antiglycation activities, and hepatoprotective potential. There is a relationship between vitamin D deficiency (VDD) and the severity of liver disorders. VDD has been proposed to contribute to the progression of nonalcoholic fatty liver disease (NAFLD). However, experimental results are not clear. Therefore, in this study, the effects of a VDD diet on high fructose (HFr) drinking-induced NAFLD was evaluated.