Variation in the attachment of Streptococcus pneumoniae to human pharyngeal epithelial cells after treatment with S-carboxymethylcysteine

Suer E., Sayrac S., Sarinay E., Ozturk H. E., Turkoz M., Ichinose A., ...Daha Fazla

Journal of Infection and Chemotherapy, cilt.14, sa.4, ss.333-336, 2008 (Scopus) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 14 Sayı: 4
  • Basım Tarihi: 2008
  • Doi Numarası: 10.1007/s10156-008-0626-z
  • Dergi Adı: Journal of Infection and Chemotherapy
  • Derginin Tarandığı İndeksler: Scopus
  • Sayfa Sayıları: ss.333-336
  • Anahtar Kelimeler: Epithelial cells, Human, S-carboxymethylcysteine, Streptococcus pneumoniae
  • Acıbadem Mehmet Ali Aydınlar Üniversitesi Adresli: Hayır

Özet

S-carboxymethylcysteine (S-CMC) is a mucolytic agent that can prevent respiratory infection by decreasing the attachment of respiratory pathogens to human pharyngeal epithelial cells (HPECs). Streptococcus pneumoniae is a major cause of respiratory infections. A previous study revealed that treatment of S. pneumoniae with S-CMC caused a decrease in the attachment of this bacterium to HPECs. In the present study we found that the effect of S-CMC varied according to hosts and strains. S-CMC treatment altered the surface structure of S. pneumoniae, resulting in a decrease of attachment, without affecting the virulence of the bacteria. © 2008 Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases.