Variation in the attachment of Streptococcus pneumoniae to human pharyngeal epithelial cells after treatment with S-carboxymethylcysteine

Suer E., Sayrac S., Sarinay E., Ozturk H. E. , Turkoz M., Ichinose A., ...More

Journal of Infection and Chemotherapy, vol.14, no.4, pp.333-336, 2008 (Scopus) identifier identifier

  • Publication Type: Article / Article
  • Volume: 14 Issue: 4
  • Publication Date: 2008
  • Doi Number: 10.1007/s10156-008-0626-z
  • Journal Name: Journal of Infection and Chemotherapy
  • Journal Indexes: Scopus
  • Page Numbers: pp.333-336
  • Keywords: Epithelial cells, Human, S-carboxymethylcysteine, Streptococcus pneumoniae
  • Acibadem Mehmet Ali Aydinlar University Affiliated: Yes


S-carboxymethylcysteine (S-CMC) is a mucolytic agent that can prevent respiratory infection by decreasing the attachment of respiratory pathogens to human pharyngeal epithelial cells (HPECs). Streptococcus pneumoniae is a major cause of respiratory infections. A previous study revealed that treatment of S. pneumoniae with S-CMC caused a decrease in the attachment of this bacterium to HPECs. In the present study we found that the effect of S-CMC varied according to hosts and strains. S-CMC treatment altered the surface structure of S. pneumoniae, resulting in a decrease of attachment, without affecting the virulence of the bacteria. © 2008 Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases.