Congenital Adrenal Hyperplasia as a Cause of Secondary Hypertension in Adults: Three Cases


Anaforoglu İ., Algun E., Ersoy K.

TURKISH JOURNAL OF ENDOCRINOLOGY AND METABOLISM, cilt.23, sa.2, ss.135-140, 2019 (ESCI) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 23 Sayı: 2
  • Basım Tarihi: 2019
  • Doi Numarası: 10.25179/tjem.2019-65085
  • Dergi Adı: TURKISH JOURNAL OF ENDOCRINOLOGY AND METABOLISM
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.135-140
  • Anahtar Kelimeler: Congenital adrenal hyperplasia, secondary hypertension, hypertension, hypokalemia, DEFICIENCY, DIAGNOSIS, FORMS
  • Acıbadem Mehmet Ali Aydınlar Üniversitesi Adresli: Hayır

Özet

Congenital adrenal hyperplasia is a group of hereditary disorders originating from enzymatic defects in steroidogenesis, resulting in impaired cortisol synthesis in the adrenal cortex. The rare forms of congenital adrenal hyperplasia characterized by hypertension and hypokalemia include 11-beta and 17-alpha hydroxylase deficiencies. We described three cases of congenital adrenal hyperplasia, two with 11-alpha hydroxylase and one with 17-alpha hydroxylase deficiency, each presenting with hypertension and hypokalemia in adulthood. In addition, 11-beta hydroxylase deficiency cases showed precocious puberty with testicular adrenal rest tumor and adrenal myelolipoma, whereas the patient with 17-alpha hydroxylase deficiency showed sexual infantilism. Congenital adrenal hyperplasia is a rare cause of secondary hypertension in adults. It is particularly considered in patients with sexual maturation disorders, such as precocious puberty, delayed puberty, or sexual infantilism, and in those with hypertension and hypokalemia.