Pharmacological modulation of vascular ageing: A review from VascAgeNet

Anacak G. Y.

Final workshop of VascAgeNet, Riga, Letonya, 20 - 21 Mart 2024

  • Yayın Türü: Bildiri / Yayınlanmadı
  • Basıldığı Şehir: Riga
  • Basıldığı Ülke: Letonya
  • Acıbadem Mehmet Ali Aydınlar Üniversitesi Adresli: Evet

Özet

Pharmacological modulation of endothelial dysfunction and arterial stiffness as hallmarks of vascular ageing, holds great promise for improving cardiovascular health in the ageing population.

 The multi-faceted nature of vascular ageing complicates the evaluation of drugs. Interactions with exercise training and sex/gender-related differences, which should be taken into account

Pharmacological modulation of mechanisms and signalling pathways that contribute to vascular ageing are involving

·        Oxidative stress

·        Renin-angiotensin-aldosterone system

·       Cellular senescence

·       Macroautophagy

·        Extracellular matrix remodelling

·        Calcification

·        Gasotransmitters

There are also approved drugs with off-label effects on vascular ageing and we should not e that dietary supplements have some limited effects on vascular ageing

At present, there are no approved drugs specifically targeting arterial stiffness and endothelial dysfunction. Some available cardiovascular and anti-diabetic drugs can modulate vascular ageing. Novel promising drugs are currently evaluated in preclinical and clinical trials.

 

Further research is needed to fully elucidate the underlying mechanisms and optimize the efficacy and safety of these interventions for clinical translation.